Melanocortin & Endocrine Research

Melanocortin peptides act on five POMC-derived G-protein-coupled receptors (MC1R–MC5R) across diverse tissues. PT-141 is a cyclic melanocortin agonist studied for its central effects on hypothalamic arousal circuits. Kisspeptin is the master regulator of the hypothalamic-pituitary-gonadal axis, investigated for puberty onset and reproductive function. Oxytocin is a nonapeptide studied for social bonding and stress modulation. VIP is a 28-amino-acid neuropeptide with vasodilatory, immunomodulatory, and neuroprotective properties.

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