Buy PTD-DBM Research Peptide

Chimeric fusion of a cell-penetrating TAT protein transduction domain with a Dishevelled-binding motif produced PTD-DBM, a bifunctional construct engineered to deliver an intracellular Wnt pathway interaction domain across cell membranes without requiring transfection. Also known as TAT-DBM chimeric peptide, approximate molecular weight of 2000 g/mol. Produced via solid-phase peptide synthesis.

In vitro studies using Wnt-responsive reporter cell lines have investigated whether PTD-DBM competitively inhibits Dvl-Frizzled interaction and reduces TCF/LEF-dependent transcriptional output in a dose-dependent manner. In vivo rodent models have explored the biodistribution and cellular uptake efficiency of PTD-DBM in tissues with active Wnt signalling, examining whether the TAT-mediated delivery strategy achieves sufficient intracellular concentrations to modulate Dvl-dependent beta-catenin stabilisation.

Manufactured in a quality-controlled laboratory to a guaranteed purity of 98% or above. Every batch undergoes independent third-party testing using HPLC and MS-UPLC analysis before dispatch. Vials are vacuum sealed and stored in a temperature-controlled, monitored cold storage system. A batch-specific Certificate of Analysis is available on request.

Sold strictly for in vitro research purposes only. Not for human consumption. Intended for use by qualified researchers in laboratory settings only.