SS-31 (Elamipretide) research peptide — ≥98% purity by HPLC — CAS 736992-21-5 — also known as Elamipretide, MTP-131, Bendavia, Szeto-Schiller 31 — lyophilized powder for in-vitro laboratory research — Peptides.net
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Buy SS-31 (Elamipretide) Research Peptide

SS-31 is available as a lyophilised powder, independently HPLC and MS-UPLC tested to ≥98% purity.

639.80 g/mol≥98% (HPLC)736992-21-5

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≥98% purity

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What is SS-31 (Elamipretide)?

A synthetic four-amino-acid peptide that targets the inner membrane of mitochondria, also known as elamipretide, SS-31 is studied for its effects on cellular energy production and age-related decline in tissue function. Research focuses on its binding to cardiolipin, a key mitochondrial lipid, and its protection of the energy-producing electron transport chain.

  • Studied for its binding to cardiolipin in the inner mitochondrial membrane.
  • Investigated in research models for electron-transport-chain protection.
  • Examined for its effects on mitochondrial energy production in vitro.
  • Used as a research tool to study mitochondrial dysfunction.

For research use only. Not intended for human use.

Engineered with alternating aromatic and cationic residues to exploit the electrochemical gradient across the inner mitochondrial membrane, SS-31 is a cell-permeable tetrapeptide that has become a primary pharmacological tool in mitochondrial cardiolipin research. Also known as Elamipretide, MTP-131, or Bendavia, carries the molecular formula C32H54N10O5 and a molecular weight of 675.85 g/mol. Its sequence D-Arg-2,6-Dmt-Lys-Phe-NH2 incorporates a D-arginine and a dimethyltyrosine residue. Produced via solid-phase peptide synthesis.

In vitro studies using isolated mitochondria and submitochondrial particles have examined whether MTP-131 stabilises cardiolipin-cytochrome c interactions and modulates electron transport chain complex activity. In vivo rodent models have investigated the mitochondrial uptake kinetics of Bendavia using fluorescently labelled analogues, mapping the relationship between membrane potential, SS-31 accumulation and respiratory control ratio.

Manufactured in a quality-controlled laboratory to a guaranteed purity of 98% or above. Every batch undergoes independent third-party testing using HPLC and MS-UPLC analysis before dispatch. Vials are vacuum sealed and stored in a temperature-controlled, monitored cold storage system. A batch-specific Certificate of Analysis is available on request.

Sold strictly for in vitro research purposes only. Not for human consumption. Intended for use by qualified researchers in laboratory settings only.

Scientific Review

Dr. Cristina Cosi

Scientific review

Dr. Cristina Cosi

Scientific Contributor and Reviewer

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Every batch is HPLC-tested to ≥98% purity. Certificate of Analysis and SDS available on request.

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