Buy PNC-27 Research Peptide

Chimeric peptide design linking a p53-derived MDM-2 binding domain to a membrane-disrupting leader sequence produced the 32-amino acid construct PNC-27, a compound that has generated preclinical interest at the intersection of tumour suppressor biology and membrane biophysics. Also known as p53 chimeric peptide, approximate molecular weight of 3800 g/mol. Produced via solid-phase peptide synthesis.

In vitro studies using panels of transformed and non-transformed cell lines have examined whether PNC-27 binds selectively to surface-expressed HDM-2 and induces membrane pore formation, as assessed by lactate dehydrogenase release and electron microscopy. In vivo rodent xenograft models have investigated the biodistribution and tumour localisation of fluorescently labelled PNC-27, examining whether surface HDM-2 expression levels correlate with peptide accumulation.

Manufactured in a quality-controlled laboratory to a guaranteed purity of 98% or above. Every batch undergoes independent third-party testing using HPLC and MS-UPLC analysis before dispatch. Vials are vacuum sealed and stored in a temperature-controlled, monitored cold storage system. A batch-specific Certificate of Analysis is available on request.

Sold strictly for in vitro research purposes only. Not for human consumption. Intended for use by qualified researchers in laboratory settings only.