Buy Orexin A Research Peptide

Dual agonism at both OX1R and OX2R receptor subtypes distinguishes this 33-amino acid neuropeptide as a structurally complex and pharmacologically versatile research tool. Orexin A, also known as Hypocretin-1 (CAS 205640-90-0), carries the molecular formula C152H251N41O44S3 and a molecular weight of 3561.97 g/mol. The peptide features two intramolecular disulphide bonds and an N-terminal pyroglutamate residue. Produced via solid-phase peptide synthesis.

In vitro studies using hypothalamic neuron cultures have examined Orexin A-mediated activation of Gq-coupled calcium mobilisation and Gi-coupled cAMP inhibition, investigating how receptor subtype co-expression influences integrated intracellular signalling output. In vivo rodent models have explored the effects of central Hypocretin-1 administration on lateral hypothalamic neuronal firing patterns and downstream arousal circuit engagement.

Manufactured in a quality-controlled laboratory to a guaranteed purity of 98% or above. Every batch undergoes independent third-party testing using HPLC and MS-UPLC analysis before dispatch. Vials are vacuum sealed and stored in a temperature-controlled, monitored cold storage system. A batch-specific Certificate of Analysis is available on request.

Sold strictly for in vitro research purposes only. Not for human consumption. Intended for use by qualified researchers in laboratory settings only.