Buy DNSP-11 Research Peptide

Identification of a biologically active fragment within the prosequence of glial cell line-derived neurotrophic factor — a region normally cleaved and discarded during propeptide processing — introduced DNSP-11 as a structurally novel research tool in neurotrophic signalling. Also known as GDNF prosequence peptide, this 11-amino acid C-terminally amidated compound has an approximate molecular weight of 1300 g/mol. Produced via solid-phase peptide synthesis.

In vitro studies using dopaminergic MN9D cell lines have investigated whether GDNF prosequence peptide activates PI3K/Akt and MAPK/ERK cascades through GFRa1/RET-dependent or RET-independent mechanisms. In vivo rodent models have explored the biodistribution and CNS penetration of GDNF prosequence peptide, examining whether the 11-amino acid fragment achieves sufficient nigral tissue concentrations to engage local neurotrophic signalling pathways.

Manufactured in a quality-controlled laboratory to a guaranteed purity of 98% or above. Every batch undergoes independent third-party testing using HPLC and MS-UPLC analysis before dispatch. Vials are vacuum sealed and stored in a temperature-controlled, monitored cold storage system. A batch-specific Certificate of Analysis is available on request.

Sold strictly for in vitro research purposes only. Not for human consumption. Intended for use by qualified researchers in laboratory settings only.