Colivelin research peptide — ≥98% purity by HPLC — CAS 867021-83-8 — also known as CLN, ADNF-HNG17 Chimeric Peptide — lyophilized powder for in-vitro laboratory research — Peptides.net
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Buy Colivelin Research Peptide

Colivelin is available as a lyophilised powder, independently HPLC and MS-UPLC tested to ≥98% purity.

2,645.30 g/mol≥98% (HPLC)867021-83-8

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≥98% purity

Lyophilised

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What is Colivelin?

A synthetic hybrid peptide fusing two separate neuroprotective sequences into a single chain, Colivelin is studied for its protection of nerve cells. Research focuses on how it activates two distinct signalling cascades at once, one from each of its component domains.

  • Studied for its activation of two distinct neuronal survival signalling cascades.
  • Investigated in research models for neuronal survival pathways.
  • Examined in vitro for activity in cultured neurons under stress.
  • Used as a research tool to study combined signalling domains.

For research use only. Not intended for human use.

Chimeric peptide engineering fusing an activity-dependent neurotrophic factor fragment with a Humanin-derived sequence produced the 26-amino acid construct Colivelin, a compound engaging multiple neuroprotective signalling axes within a single molecular framework. Also designated ADNF-HN chimeric peptide, approximate molecular weight of 3000 g/mol. Produced via solid-phase peptide synthesis.

In vitro studies using cortical neuron preparations have investigated whether Colivelin engages both the STAT3-dependent pathway attributed to Humanin and the VPAC2/cAMP axis attributed to ADNF-9. In vivo rodent models have explored whether the chimeric construct achieves CNS bioavailability and tissue distribution distinct from that of its individual component peptides administered separately.

Manufactured in a quality-controlled laboratory to a guaranteed purity of 98% or above. Every batch undergoes independent third-party testing using HPLC and MS-UPLC analysis before dispatch. Vials are vacuum sealed and stored in a temperature-controlled, monitored cold storage system. A batch-specific Certificate of Analysis is available on request.

Sold strictly for in vitro research purposes only. Not for human consumption. Intended for use by qualified researchers in laboratory settings only.

Scientific Review

Dr. Cristina Cosi

Scientific review

Dr. Cristina Cosi

Scientific Contributor and Reviewer

Currently under review

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Batch-specific Certificate of Analysis available on request

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Every batch is HPLC-tested to ≥98% purity. Certificate of Analysis and SDS available on request.

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