Buy ACE-031 Research Protein
ACE-031 is supplied as a lyophilised powder, independently HPLC and MS-UPLC tested to ≥98% purity.
Buy ACE-031 Research Protein
ACE-031 is supplied as a lyophilised powder, independently HPLC and MS-UPLC tested to ≥98% purity.
HPLC Verified
≥98% purity
Lyophilised
Powder format
Express Shipping
Cold-chain included
COA Available
Every batch
HPLC Verified
≥98% purity
Lyophilised
Powder format
Express Shipping
Cold-chain included
COA Available
Every batch
Same or Next Day Dispatch
Order before 12pm GMT for same-day dispatch; after 12pm ships next business day
Same or Next Day Dispatch
Order before 12pm GMT for same-day dispatch; after 12pm ships next business day
What is ACE-031?
A recombinant fusion protein that acts as a molecular sponge, also known as ActRIIB-Fc, ACE-031 is studied for its effects on skeletal muscle mass. Research focuses on how it traps several growth-regulating proteins at once, including myostatin, rather than blocking a single target.
- Studied for its activity as a soluble decoy at the activin type II receptor (ActRIIB).
- Investigated in research models for its binding of myostatin and related TGF-beta ligands.
- Examined for its capacity to sequester several growth-regulating ligands at once.
- Used as a research tool to study the myostatin signalling axis in skeletal muscle models.
For research use only. Not intended for human use.
Fusion of the extracellular domain of the activin type IIB receptor to an immunoglobulin Fc fragment created a soluble decoy receptor central to TGF-beta ligand-trapping research. ACE-031, also designated ACVR2B-Fc or ActRIIB-Fc, is a recombinant fusion protein with an approximate molecular weight of 60,000 g/mol. Produced as a recombinant protein.
In vitro surface plasmon resonance assays have measured the binding kinetics of ACE-031 against a panel of TGF-beta ligands including GDF-8, GDF-11, activin A and activin B. In vivo rodent models have investigated the downstream consequences of broad-spectrum ligand sequestration by ActRIIB-Fc on SMAD2/3 phosphorylation status across multiple tissue types.
Manufactured in a quality-controlled laboratory to a guaranteed purity of 98% or above. Every batch undergoes independent third-party testing using HPLC and MS-UPLC analysis before dispatch. Vials are vacuum sealed and stored in a temperature-controlled, monitored cold storage system. A batch-specific Certificate of Analysis is available on request.
Sold strictly for in vitro research purposes only. Not for human consumption. Intended for use by qualified researchers in laboratory settings only.
Scientific Review
Scientific review
Dr. Cristina Cosi
Scientific Contributor and Reviewer
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Quality Guaranteed
Every batch is HPLC-tested to ≥98% purity. Certificate of Analysis and SDS available on request.