N-terminal conjugation of a palmitoyl fatty acid chain to the Gly-His-Lys tripeptide scaffold created a lipopeptide analogue investigated for its altered membrane interaction and cellular uptake properties. PAL-GHK, also known as Palmitoyl Tripeptide-1 or Palmitoyl-GHK (CAS 147732-56-7), carries the molecular formula C30H54N6O5 and a molecular weight of 594.79 g/mol. The C16 palmitoyl chain confers amphiphilic character absent in the parent GHK tripeptide. Produced via solid-phase peptide synthesis with subsequent lipid conjugation.

In vitro studies using human fibroblast monolayers have compared the capacity of Palmitoyl-GHK and unconjugated GHK to modulate collagen I and fibronectin gene expression. In vivo rodent models have explored the dermal retention and depot formation characteristics of Palmitoyl Tripeptide-1, investigating whether the palmitoyl chain confers prolonged local tissue residence.

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