Buy IGF-1 DES Research Peptide

Removal of the first three amino acids from the native IGF-1 N-terminus yields a truncated 67-amino acid analogue with markedly altered binding protein interactions. Des(1-3)IGF-1, commonly referred to as IGF-1 DES (CAS 67763-96-6), carries a molecular weight of 7371.39 g/mol. The N-terminal truncation substantially diminishes affinity for several IGF-binding proteins while preserving IGF-1 receptor recognition. Produced via solid-phase peptide synthesis.

In vitro competitive binding assays have quantified the displacement characteristics of IGF-1 DES relative to full-length IGF-1 at IGFBP-1 through IGFBP-6. In vivo rodent investigations have examined whether the reduced sequestration of IGF-1 DES alters the kinetics of IGF-1R phosphorylation and downstream MAPK/ERK cascade engagement.

Manufactured in a cGMP compliant laboratory to a guaranteed purity of 98% or above. Every batch undergoes independent testing using HPLC and MS-UPLC analysis before dispatch. Vials are vacuum sealed and stored in a temperature controlled, monitored cold storage system. Certificates of Analysis are available on request.

Sold strictly for in vitro research purposes only. Not for human consumption. Intended for use by qualified researchers in laboratory settings only.