Buy Dermorphin Research Peptide

Originally isolated from the skin secretions of South American phyllomedusine frogs, Dermorphin is a naturally occurring heptapeptide and one of the first known examples of a D-amino acid-containing peptide in a vertebrate organism. Also designated Dermorphin natural heptapeptide (CAS 77614-16-5), carries the molecular formula C40H51N7O10 and a molecular weight of 785.88 g/mol. Its sequence Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2 features a D-alanine at position 2. Produced via solid-phase peptide synthesis and is a highly selective mu-opioid receptor agonist.

In vitro radioligand displacement assays using membrane preparations expressing MOR, DOR and KOR have characterised the binding selectivity ratios of Dermorphin across the three classical opioid receptor subtypes. In vivo rodent models have explored the enzymatic stability of the D-Ala2-containing sequence relative to L-Ala2 substituted analogues, examining how the stereochemical inversion at position 2 influences aminopeptidase resistance.

Manufactured in a quality-controlled laboratory to a guaranteed purity of 98% or above. Every batch undergoes independent third-party testing using HPLC and MS-UPLC analysis before dispatch. Vials are vacuum sealed and stored in a temperature-controlled, monitored cold storage system. A batch-specific Certificate of Analysis is available on request.

Sold strictly for in vitro research purposes only. Not for human consumption. Intended for use by qualified researchers in laboratory settings only.