Buy TB-500 Research Peptide
TB-500 is available as a lyophilised powder, independently HPLC and MS-UPLC tested to ≥98% purity.
Buy TB-500 Research Peptide
TB-500 is available as a lyophilised powder, independently HPLC and MS-UPLC tested to ≥98% purity.
HPLC Verified
≥99% purity
Lyophilised
Powder format
Express Shipping
Cold-chain included
COA Available
Every batch
HPLC Verified
≥99% purity
Lyophilised
Powder format
Express Shipping
Cold-chain included
COA Available
Every batch
Same or Next Day Dispatch
Order before 12pm GMT for same-day dispatch; after 12pm ships next business day
Same or Next Day Dispatch
Order before 12pm GMT for same-day dispatch; after 12pm ships next business day
What is TB-500?
A synthetic version of a naturally occurring 43-amino acid protein called Thymosin Beta-4, TB-500 is studied for its role in cell movement and tissue recovery. Research centres on its ability to bind and regulate actin, a structural protein inside cells, which influences how cells migrate to sites of injury.
- In vitro studies show Thymosin Beta-4 sequesters monomeric G-actin, regulating the assembly of the actin cytoskeleton that drives cell migration.
- In rodent models of myocardial infarction, administration was associated with reduced scar volume and activation of epicardial progenitor cells.
- Dermal wound-healing studies in rodents report accelerated keratinocyte migration and increased angiogenesis at the wound margin.
- Investigations describe upregulation of laminin-5 and matrix metalloproteinases implicated in extracellular matrix remodelling during repair.
For research use only. Not intended for human use.
Derived from a synthetic fragment of the ubiquitous actin-sequestering protein Thymosin Beta-4, TB-500 is a 43-amino acid peptide that has become one of the most widely referenced actin-modulating compounds in preclinical cell biology research. Also known as Thymosin Beta-4 fragment, approximate molecular weight of 4963 g/mol. The actin-binding domain of TB-500 is centred on the LKKTETQ motif. Produced via solid-phase peptide synthesis.
In vitro studies using scratch wound and transwell migration assays have investigated whether TB-500 modulates actin polymerisation dynamics through G-actin sequestration and its influence on Rac1/Cdc42-mediated lamellipodia formation. In vivo rodent models have examined the tissue distribution of exogenously administered Thymosin Beta-4 fragment, investigating whether the peptide achieves localisation at sites of active cytoskeletal remodelling.
Manufactured in a quality-controlled laboratory to a guaranteed purity of 98% or above. Every batch undergoes independent third-party testing using HPLC and MS-UPLC analysis before dispatch. Vials are vacuum sealed and stored in a temperature-controlled, monitored cold storage system. A batch-specific Certificate of Analysis is available on request.
Sold strictly for in vitro research purposes only. Not for human consumption. Intended for use by qualified researchers in laboratory settings only.
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Quality Guaranteed
Every batch is HPLC-tested to ≥98% purity. Certificate of Analysis and SDS available on request.