Buy IGF-1 DES Research Protein

Removal of the first three amino acids from the native IGF-1 N-terminus yields a truncated 67-amino acid analogue with markedly altered binding protein interactions. Des(1-3)IGF-1, commonly referred to as IGF-1 DES (CAS 67763-96-6), carries a molecular weight of 7371.39 g/mol. The N-terminal truncation substantially diminishes affinity for several IGF-binding proteins while preserving IGF-1 receptor recognition. Produced via solid-phase peptide synthesis.

In vitro competitive binding assays have quantified the displacement characteristics of IGF-1 DES relative to full-length IGF-1 at IGFBP-1 through IGFBP-6. In vivo rodent investigations have examined whether the reduced sequestration of IGF-1 DES alters the kinetics of IGF-1R phosphorylation and downstream MAPK/ERK cascade engagement.

Manufactured in a quality-controlled laboratory to a guaranteed purity of 98% or above. Every batch undergoes independent third-party testing using HPLC and MS-UPLC analysis before dispatch. Vials are vacuum sealed and stored in a temperature-controlled, monitored cold storage system. A batch-specific Certificate of Analysis is available on request.

Sold strictly for in vitro research purposes only. Not for human consumption. Intended for use by qualified researchers in laboratory settings only.