GHRP-2
HPLC Verified

Buy GHRP-2 Research Peptide

GHRP-2 is available as a lyophilised powder, independently HPLC and MS-UPLC tested to ≥98% purity. Every order ships with a batch-specific Certificate of Analysis.

817.99 g/mol≥98% (HPLC)158861-67-7

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What is GHRP-2?

A synthetic peptide of the growth hormone secretagogue class, also known as pralmorelin, GHRP-2 is studied for its capacity to stimulate growth hormone release. Research examines how it activates the ghrelin receptor and works alongside the body's own growth hormone-releasing hormone.

  • In ovine and rat pituitary somatotroph cultures, GHRP-2 stimulated growth hormone secretion via cAMP, calcium-channel and PKC/PKA signalling.
  • Rodent studies report synergistic growth hormone release when combined with growth hormone-releasing hormone.
  • Comparative work attributes its enhanced potency over GHRP-6 to substitution of a naphthylalanine residue at position two.
  • Studies describe a secondary effect on appetite signalling consistent with ghrelin-receptor agonism.

For research use only. Not intended for human use.

Second-generation growth hormone-releasing peptides introduced key structural refinements that reshaped preclinical ghrelin receptor research, and Pralmorelin stands as one of the most extensively characterised compounds in that lineage. GHRP-2, also designated KP-102 (CAS 158861-67-7), has the molecular formula C45H55N9O6 and a molecular weight of 817.99 g/mol. Its sequence D-Ala-D-2-Nal-Ala-Trp-D-Phe-Lys-NH2 incorporates a D-2-Naphthylalanine residue at position 2. Produced via solid-phase peptide synthesis.

In vitro competition binding assays using radiolabelled GHS-R1a ligands have investigated the relative displacement potency of Pralmorelin against first-generation hexapeptides and non-peptide agonists. Rodent in vivo models have explored temporal patterns of hypothalamic-pituitary axis activation following GHRP-2 administration, with particular attention to dose-dependent modulation of endogenous GHRH neuronal output.

Manufactured in a quality-controlled laboratory to a guaranteed purity of 98% or above. Every batch undergoes independent testing using HPLC and MS-UPLC analysis before dispatch. Vials are vacuum sealed and stored in a temperature controlled, monitored cold storage system. Certificates of Analysis are available on request.

Sold strictly for in vitro research purposes only. Not for human consumption. Intended for use by qualified researchers in laboratory settings only.

Editorial Team

Dr. Cristina Cosi, PhD

Scientific review

Dr. Cristina Cosi, PhD

Scientific Contributor and Reviewer

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