Buy ACE-031 Research Peptide

Fusion of the extracellular domain of the activin type IIB receptor to an immunoglobulin Fc fragment created a soluble decoy receptor central to TGF-beta ligand-trapping research. ACE-031, also designated ACVR2B-Fc or ActRIIB-Fc, is a recombinant fusion protein with an approximate molecular weight of 60,000 g/mol. Produced as a recombinant protein.

In vitro surface plasmon resonance assays have measured the binding kinetics of ACE-031 against a panel of TGF-beta ligands including GDF-8, GDF-11, activin A and activin B. In vivo rodent models have investigated the downstream consequences of broad-spectrum ligand sequestration by ActRIIB-Fc on SMAD2/3 phosphorylation status across multiple tissue types.

Manufactured in a cGMP compliant laboratory to a guaranteed purity of 98% or above. Every batch undergoes independent testing using HPLC and MS-UPLC analysis before dispatch. Vials are vacuum sealed and stored in a temperature controlled, monitored cold storage system. Certificates of Analysis are available on request.

Sold strictly for in vitro research purposes only. Not for human consumption. Intended for use by qualified researchers in laboratory settings only.