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Peptide Drugs, Overcoming the Challenges, a Growing Business
Mimoun Ayoub and Daniel Scheidegger
Due to the advances achieved in the peptide field the last few years, this class of therapeutics has continued gaining more interest. Thus peptide drugs became a focus for several pharmaceutical and biotech companies.They are used in different therapeutic areas like allergy, anti-infection, diagnostics, oncology, diabetes, obesity, cardiovascular and arthritis.
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Are low-Priced Peptides Affordable?
Rodney Lax and Michael Verlander
Towards the end of May 2006, a number of reports appeared in the press concerning the indictment of a biotechnology company and its owner on charges of allegedly shipping bogus research material to many corporate and academic researchers. According to thes ereports, the indictment alleged that employees of the company fraudulently misrepresented the purity of the peptide products they manufactured.
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Libraries of Conformationally Restricted and Rigid Amino Acids
Igor V. Komarov, Oleksandr O. Grygorenko, Dmytro S. Radchenko, Oleksiy S. Artamonov, Alexander N. Kostyuk, and Andrey A. Tolmachev
Libraries of rigid and conformationally restricted α-amino acids have good perspectives to obtain peptide models and peptidomimetics. Two mini-libraries of α-amino acids have been developed: one consisting of bicyclic proline analogues, another composed of potential glutamate receptor ligands containing spiro [3.3] heptane scaffold. Synthesis of some rigid amino acids using “chiral pool” terpenoids as starting compounds is also described.
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High Throughput Synthesis of Peptides and Peptidomimetics
Hruby V.J. and Vagner J.
The development of methods for solid phase synthesis of a variety of organic and inorganic structures using similar strategies as in peptide synthesis are being vigorously pursued. However, existing instrumentation and technology is not sufficient to cover current demands for peptides, and thus new approaches and technologies for cost-effective synthesis of peptide arrays are needed.
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Application of Enzymes for the Synthesis of the Cholecystokinin Pentapeptide (CCK-5)
Liping Meng, Rajendra Joshi and Heiner Eckstein
Application of immobilised enzymes has several advantages in comparison to free enzymes in the synthesis of peptides as therapeutical drugs. Here the principles of enzymatic peptide synthesis are discussed and their application in our peptide synthetic work with immobilised enzymes is presented.
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Synthesis of Cystine-rich Peptides
Cyril Boulèguem, Hans-Jürgen Musiol, Vidya Prasad and Luis Moroder
Since the early days of peptide chemistry the synthesis of cysteine-containing peptides has been one of the most challenging tasks, primarily because of the difficulties involved in the formation of multiple regioselective disulfide bonds. To overcome these challenges, new protection strategies and selective thiol chemistry continue to be developed. Great advances have been achieved over the years as demonstrated by the numerous highly efficient syntheses of mono- and multiple stranded Cys-rich
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The use of Microwave Irradiation in Peptide Chemistry
Paolo Grieco
The introduction of high-throughput biological screening and the accelerated discovery of new biological targets has increased the demand on synthetic chemists to produce new compounds for testing. Recently there has been growing interest in applying microwave heating for many chemical applications requiring energy input. In this paper, we will review the most interesting examples of microwave-promoted reactions in peptides and peptidomimetics synthesis.
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Fibronectin peptides in cell migration and wound repair
Fibronectin peptides in cell migration and wound repair
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Malaria - Peptides toxic to parasite development identified
Malaria - Peptides toxic to parasite development identified
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How is the human signal peptide recognized?
How is the human signal peptide recognized?
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Serum peptidome for cancer detection
Serum peptidome for cancer detection
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Synthetic Peptide Mimics Growth Factor Angiogenesis and Tissue Repair
Synthetic Peptide Mimics Growth Factor Angiogenesis and Tissue Repair
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REMUS: a tool for identification of unique peptide segments as epitopes
REMUS: a tool for identification of unique peptide segments as epitopes
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Biological junk finds use in cancer detection
Biological junk finds use in cancer detection
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Leptin: Your brain, appetite and obesity
Leptin: Your brain, appetite and obesity
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PREDTAP: a system for prediction of peptide binding to the human transporter
PREDTAP: a system for prediction of peptide binding to the human transporter
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Self-assembling peptides hold promise for creation of new biomaterials
Self-assembling peptides hold promise for creation of new biomaterials
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Absorption of Amino Acids and Peptides
Absorption of Amino Acids and Peptides
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Peptide Engineering
Peptide Engineering
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Introduction to Protein Structure
Peptides
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Peptide bond and peptides
Peptide bond and peptides
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Biological activity of small peptides
Biological activity of small peptides
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Self-Replication: Even peptides do it
Self-Replication: Even peptides do it
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Nomenclature and Symbolism for Amino Acids and Peptides
Nomenclature and Symbolism for Amino Acids and Peptides
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Protein Structure
Protein Structure
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Bioprocessing: Market Growing for Custom-Made Peptides
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