AnaSpec Introduces new Series of PAR Peptides

AnaSpec has introduced its latest series of PAR peptides.

Protease or Proteinase-Activated Receptors, PARs, belong to the seven transmembrane G-protein coupled family of receptors. These receptors are activated when the amino terminus of the receptor is cleaved by specific serine proteases - thrombin (PAR-1, 3 and 4) and trypsin (PAR-2). The cleaved amino end can then act as a tethered ligand on the second extracellular loop of the receptor thereby activating the receptor.

Short sequences contained in the amino terminus have been found to activate the receptors on their own, without the need for the protease cleavage.

PAR Peptide Series:

• PAR-1 Agonist, STAL – 2, amide

Sequence: SFLLRN-NH2

• PAR-1 Agonist, Thrombin Receptor Activator for Peptide 6 (TRAP - 6)

Sequence: SFLLRN

• Scrambled PAR-1 Agonist

Sequence: FSLLRN-NH2

• Thrombin Receptor (42 - 48) Agonist, human

Sequence: SFLLRNP

• Thrombin Receptor Agonist, amide

Sequence: SFLLR-NH2

• Thrombin Receptor Agonist

Sequence: SFLLR

• Thrombin Receptor Antagonist

Sequence: FLLRN

• SFLLRNPNDKYEPF, TRAP-14, Thrombin Receptor 42 - 55, human

Sequence: SFLLRNPNDKYEPF

• PAR - 1 Agonist

Sequence: TFLLRN

• PAR - 1 Agonist, amide

Sequence: TFLLRN-NH2

• PAR - 1 Agonist, amide

Sequence: TFLLRNPNDK-NH2

• Protease - Activated Receptor - 2, PAR - 2 Agonist, amide

Sequence: SLIGKV-NH2

• PAR - 3 Agonist, amide

Sequence: SFNGGP-NH2

• PAR - 1 Agonist, amide

Sequence: TFLLRNPNDK-NH2

• Protease - Activated Receptor - 4, PAR - 4 Agonist, amide, human

Sequence: GYPGQV-NH2

• Protease - Activated Receptor - 4, PAR - 4 Agonist, amide, murine

Sequence: GYPGKF-NH2

• N - 10 Region of TRAP

Sequence: DEIKYSEEVC.

Further Information: http://www.anaspec.com

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