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Palladium-Catalyzed Three-Component Synthesis of Phenothiazines
Troels Dahl, Christian Wenzel Tornøe, Benny Bang-Andersen, Poul Nielsen and Morten Jørgensen. H. Lundbeck A/S

The formation of aromatic carbon-heteroatom bonds has traditionally been achieved by nucleophilic aromatic substitution or via the copper-mediated Ullman reaction. The palladium-catalyzed formation of aromatic C-N bonds extensively developed by Hartwig and Buchwald has provided a powerful alternative. While the aryl amination reaction is applicable even to aryl chlorides and activated phenols, the analogous C-O and C-S bond forming reactions have attracted less attention.

Decolorization of a Vancomycin Process Stream
Jon Fisher, Amie Gehris and John Maikner. Rohm and Haas Company

Many process streams contain impurities generally given the name “color species”. These “color species” can foul resins in the upstream portion of purification processes, and must be removed in order to avoid quality problems with the pharmaceutical product.

Two-Dimensional Molecular Profiling of Multiple Myeloma
Zelena Jana, Konecna Hana, Zdrahal Zbynek, Penka Miroslav and Hajek Roman. Faculty Hospital Brno and Masaryk University

We have compared two different solubilization buffers, we also evaluated protein precipitation with ethanol and optimized 2-DE conditions for human myeloma proteins.

MS-Xelerator™: Advanced Algorithms for LC/MS Data Processing Applied to Biomarker Discovery, Differential Analysis and Quantitative Proteomics
M.M.A. Ruijken. MsMetrix

LC-MS based proteomic experiments are used to compare complex biological samples across multiple conditions. Fast, powerful computational tools are needed to explore and detect differences in the areas of Expression Proteomics and Biomarker Discovery. In general, specialized steps are necessary to solve these difficult problems (binning, alignment & normalization, peak picking, relative quantitation, etc.). MS-Xelerator is a collection of software tools dedicated to all of the above tasks.

Caveolin-1 Expression as a Possible Biomarker in Pancreatic Cancer Diagnosis
C. Tanase, E. Raducan, L. Albulescu, E. Codorean, M.I. Nicolescu, D.I. Popescu, M.L. Cruceru and A.C. Popa. Victor Babes National Institute of Pathology

Caveolin1 (Cav-1) function either as a tumor supressor or as a promoter of metastasis. Overexpresion of cav-1 was correlated with: tumoral grading, proliferration markers (Ki67, p53), serum tumor markers (CEA, CA19.9) and angiogenic markers (VEGF, bFGF).

PNA Synthesis by Novel Amide Formation
Ravi Vinayak*, Hyunil Lee, Sung Kee Kim, Jae Hoon Jeon, Jong Chan Lim, Hoon Choi, Yeohong Yoon and Hey Yeon Kim. Panagene

Benzothiazole-2-sulfonyl (Bts) has been reported as an amine-protecting group of amino acid, and the stability of sulfonamide and the mild deprotection conditions are attractive properties for a protecting group. Due to the strong electron-withdrawing effect of the sulfonyl group, the acyl group of acylsulfonamideis easily attacked by nucleophiles after alkylation which was applied in the safety-catch strategy or the synthesis of a peptide thioester for native chemical ligation of the peptide.

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